Dvl1 CLIA Kit for Mouse(Mus musculus) | EIAab.comDvl1 CLIA Kit for Mouse(Mus musculus)

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Dvl1 (Gene name),

Segment polarity protein dishevelled homolog DVL-1 (Protein name ), DVL1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Dvl1(Dvl);

Protein name:

Segment polarity protein dishevelled homolog DVL-1(Dishevelled-1);

Alternative:

DSH homolog 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CXXC4 (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site.

Function:

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling.

Subcellular Location:

Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytosol Cytoplasmic vesicle Localizes at the cell membrane upon interaction with frizzled family members.

Protein Attributes:

Sequence length:

695

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

695:

YAVVGGPPGG | PPVRELAAVP | PELTGSRQSF | QKAMGNPCEF | FVDIM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P51141

String:

P51141

Pfam:

PF00610

UniGene:

Mm.3400

KEGG:

mmu:13542

Uniprot:

P51141

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ELISA Kit for Mouse Dishevelled-1

Cat.:

E15104h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Dishevelled-1

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ELISA Kit for Mouse Dishevelled-1

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CLIA Kit for Mouse Dishevelled-1

MSDS:

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CLIA Kit for Mouse Dishevelled-1

MSDS:

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CLIA Kit for Mouse Dishevelled-1

Cat.:

U15104h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Dishevelled-1

Monoclonal Antibody for Mouse Dishevelled-1

Protein for Mouse Dishevelled-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled."
Sussman D.J. , Klingensmith J. , Salinas P. , Adams P.S. , Nusse R. , Perrimon N.
Dev. Biol.166:73-86(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Brain.
2.

"Organization and promoter analysis of the mouse dishevelled-1 gene."
Lijam N. , Sussman D.J.
Genome Res.5:116-124(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: BALB/c.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: NOD.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Embryo.
7.

"Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1."
Lijam N. , Paylor R. , McDonald M.P. , Crawley J.N. , Deng C.-X. , Herrup K. , Stevens K.E. , Maccaferri G. , McBain C.J. , Sussman D.J. , Wynshaw-Boris A.
Cell90:895-905(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
8.

"Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1."
Luo Z.G. , Wang Q. , Zhou J.Z. , Wang J. , Luo Z. , Liu M. , He X. , Wynshaw-Boris A. , Xiong W.C. , Lu B. , Mei L.
Neuron35:489-505(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT;INTERACTION WITH MUSK AND PAK1
9.

"BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta."
Kim S. , Lee J. , Park J. , Chung J.
Cancer Res.63:4792-4795(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRD7
10.

"Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."
Lu W. , Yamamoto V. , Ortega B. , Baltimore D.
Cell119:97-108(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RYK
11.

"Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1."
Pan W.J. , Pang S.Z. , Huang T. , Guo H.Y. , Wu D. , Li L.
Cell Res.14:324-330(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FZD7;MUTAGENESIS OF LYS-438;DOMAIN
12.

"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
Torban E. , Wang H.-J. , Groulx N. , Gros P.
J. Biol. Chem.279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VANGL1 AND VANGL2
13.

"The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled."
Funato Y. , Michiue T. , Asashima M. , Miki H.
Nat. Cell Biol.8:501-508(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NXN
14.

"Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl."
Tauriello D.V. , Haegebarth A. , Kuper I. , Edelmann M.J. , Henraat M. , Canninga-van Dijk M.R. , Kessler B.M. , Clevers H. , Maurice M.M.
Mol. Cell37:607-619(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH CYLD
15.

"Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway."
Wong H.C. , Mao J. , Nguyen J.T. , Srinivas S. , Zhang W. , Liu B. , Li L. , Wu D. , Zheng J.
Nat. Struct. Biol.7:1178-1184(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 395-495;FUNCTION;MUTAGENESIS OF LYS-438; ASP-449 AND ASP-452
16.

"Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled."
Wong H.C. , Bourdelas A. , Krauss A. , Lee H.J. , Shao Y. , Wu D. , Mlodzik M. , Shi D.L. , Zheng J.
Mol. Cell12:1251-1260(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 251-345;INTERACTION WITH DACT1 AND FZD7
17.

"Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled."
Lee H.J. , Wang N.X. , Shi D.L. , Zheng J.J.
Angew. Chem. Int. Ed.48:6448-6452(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 248-337 IN COMPLEX WITH SULINDAC;INTERACTION WITH DACT1;FUNCTION
18.

"Molecular basis of Wnt activation via the DIX-domain protein Ccd1."
Liu Y.T. , Dan Q.J. , Wang J. , Feng Y. , Chen L. , Liang J. , Li Q. , Lin S.C. , Wang Z.X. , Wu J.W.
J. Biol. Chem.286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 4-104;MUTAGENESIS OF TYR-17;DOMAIN;SUBUNIT

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